Barcelona are unbeaten in their 16 matches in all competitions and are heavy favourites heading into this tie. Lionel Messi and Luis Suarez should have a field day against United’s defence.
Manchester United- Manchester United can welcome back Paul Pogba from suspension in the Champions League and their injury woes have eased since they played Paris Saint-Germain last time in the competition.
Juan Mata, Jesse Lingard, Anthony Martial and Phil Jones all missed out against PSG but are all back now. Alexis Sanchez, Eric Bailly, Antonio Valencia and Matteo Darmian are all expected to miss out for the home side.
Nemanja Matic and Ander Herrera both missed training on the eve of Wednesday’s game and are now considered huge doubts. Missing their experience and pedigree would be a huge blow for United.
Ashley Young, Luke Shaw, Herrera, Matic and Valencia are all one booking away from missing the return leg.
Barcelona- Ousmane Dembele will reportedly be fit enough to make the bench against Manchester United on Wednesday.
Rafinha is ruled out for the Barcelona, while Nélson Semedo is one booking away from a one-match ban in the competition.
Samuel Umtiti has not looked overly convincing since returning from injury, which should see Clement Lenglet continue at the back.
Sergi Roberto or Semedo will get the nod at right-back.
Barcelona are undefeated in their last 8 matches (UEFA Champions League).
Who will win?