Chelsea have won their last seven matches in a row in all competitions.
Manchester United have won successive away games in all competitions for the first time since March.
United’s 2-0 win away to Chelsea in February was their first victory at Stamford Bridge since 2012.
Chelsea are slight favourites heading into Wednesday’s match and will expect to progress to the next round of the Carabao Cup.
Chelsea-N’Golo Kante, Ross Barkley, Andreas Christensen and Antonio Rudiger are all expected to miss out for Chelsea on Wednesday night. Ruben Loftus-Cheek is also sidelined. For Boosted Odds, Bet Now on NaijaBet
Christian Pulisic scored a hat-trick against Burnley on Saturday and Frank Lampard may look to pair him with Callum Hudson-Odoi on the flanks in midweek.
Michy Batshuayi and Olivier Giroud will hope to benefit from rotation to get a rare start up front.
Manchester United-Ole Gunnar Solskjaer has revealed Paul Pogba is out until December as he continues to recover from a foot injury.
Diogo Dalot, Nemanja Matic and Luke Shaw have not travelled with the Manchester United squad and will miss out once again.
The United boss may feel inclined to revert back to a three-man defence at Stamford Bridge after it worked effectively against Liverpool.
Marcos Rojo or Phil Jones will start as one of the three centre-backs as Axel Tuanzebe has failed to recover from injury in time.
Jesse Lingard, Juan Mata and Andreas Pereira compete to play as United’s No.10 on Wednesday.
Who will win?