Manchester City will be out to avenge their 2-1 defeat at home to Manchester United at the start of December.
City have won the last two matches between the two sides at Old Trafford.
United’s absences in midfield makes City overwhelming favourites despite the outcome of their meeting earlier in the season.
Manchester United- Anthony Martial and Jesse Lingard missed Saturday’s FA Cup third round tie with Wolves through illness and both remain doubts here.
Scott McTominay and Paul Pogba remain sidelined for Manchester United and that is a crushing blow ahead of their Carabao Cup first leg on Tuesday. Bet Now on NaijaBet
Ole Gunnar Solskjaer has also revealed Luke Shaw and Harry Maguire are doubts. The latter played through the pain in Saturday’s draw with Wolves. Brandon Williams or Ashley Young are on standby to replace Shaw here.
Diogo Dalot returned to the matchday squad against Wolves after a long spell out injured.
Sergio Romero could keep his place in goal as United’s goalkeeper for the cup competitions.
Leroy Sane is the only player not in training for Manchester City but this game will come too soon for Aymeric Laporte.
Nicolas Otamendi has overcome injury but youngster Eric Garcia may continue at the back for now.
David Silva marked his comeback from injury to captain the side against Port Vale.
Kevin De Bruyne, Rodrigo, Raheem Sterling, Kyle Walker, Benjamin Mendy, Eric Garcia and Fernandinho will return to the side here.
Who will win?