Messi has also endured an injury-interrupted season.
After regaining fitness, he quickly found form, scoring 24 goals in 31 appearances to help Barcelona sit two points clear at the top of LaLiga.
Setien also gave an update on the fitness of Luis Suarez, who has been given the green light by the club to return after undergoing surgery on his right knee in January.
LaLiga will resume on Thursday with Sevilla against Real Betis after a three-month break due to the coronavirus pandemic.
There are 11 rounds left to play, with fixtures expected to take place every day until the season ends on July 19.